Before going to bed at night, apply a dab of toothpaste directly to the pimple. Allow the toothpaste to dry before letting it come into contact with your pillow. Wash off the toothpaste in the morning, and you will see a noticeable reduction in the swelling. Only use white toothpaste rather than the gel kind. This is suitable for individual spot treatments only and should never be applied to the entire face.